NEW YORK — Seeking to refocus his presidential campaign, Donald Trump will lambaste Democratic rival Hillary Clinton as a failed secretary of state who is out of step with Americans on trade and immigration.

Trump’s address Wednesday morning at his hotel in New York’s SoHo neighborhood marks his official opening salvo against Clinton, the prospective Democratic presidential nominee, in the general election. It comes as Trump faces growing questions about his readiness not just for the presidency, but for the campaign he will need to run to get there.

The Trump campaign is hoping the speech can quiet those concerns and rally Republicans around their shared opposition to Clinton. The billionaire businessman plans to focus in particular on Clinton’s tenure at the State Department, arguing that her foreign policy is in part responsible for the creation of the Islamic State militant group.

“Hillary Clinton had a four-year tryout for the presidency as secretary of state,” said Stephen Miller, a Trump policy adviser. “She ran the State Department and the world went up in flames. Everything took a nosedive, except for Hillary Clinton’s bank account — which swelled to new highs.”

Trump is also expected to cite Clinton’s past support for trade deals and her willingness, along with her husband, former President Bill Clinton, to accept speaking fees and contributions to their foundation from countries with poor human rights records.