MINNEAPOLIS — Jose Abreu hit a two-run homer in the first inning of the second game of a doubleheader to spoil Zack Littell’s major league debut and help Chicago bounce back from a late lapse in the opener, and the White Sox beat the Twins 6-3 for a split on Tuesday.

In the first game, Eduardo Escobar hit a three-run homer with two outs in the eighth for the Twins in a 4-2 victory that ruined a stellar start by White Sox right-hander Reynaldo Lopez.

Abreu, who hit an RBI double in the opener, hit a first-pitch fastball from Littell (0-1) left over the middle of the plate onto the grass berm beyond center field. With an RBI single by Kevan Smith and an RBI double by Adam Engel, the White Sox staked starter Lucas Giolito (4-6) to a 4-0 lead. Giolito took advantage of the early cushion and completed six innings, and a two-run double by Yolmer Sanchez in the fourth provided further support.

Littell, added as the 26th player for the doubleheader, was acquired last July 30 from the New York Yankees in a trade for starting pitcher Jaime Garcia. The 22-year-old got nine outs, allowing six runs on six hits and four walks.

Escobar did his best to bring the Twins back again, with RBI doubles in the third and the eighth innings. The White Sox bullpen held this time, though. Luis Avilan struck out Max Kepler with men on second and third in the eighth, and Joakim Soria fanned Mitch Garver. Soria had runners at the corners in the ninth, but he finished his fifth save in seven opportunities.

Escobar went 5 for 8 with five RBIs in the doubleheader. Traded to the Twins in 2012 for starting pitcher Francisco Liriano, Escobar is batting .325 with nine doubles, four homers and 17 RBIs in his past 23 games against the White Sox.