MINNEAPOLIS — Trevor Plouffe had a chance to rally the Twins late in the game. Minnesota’s top hitter just missed a pitch and the Twins suffered another frustrating loss.

Zack Greinke pitched six strong innings and reliever Chris Withrow retired Plouffe to get out of a seventh-inning jam as the Los Angeles Dodgers defeated the Twins 6-4 on Wednesday night.

Greinke (5-0) struck out six and didn’t allow an earned run, but he loaded the bases with two outs in the seventh and the Twins trailing 5-1. Withrow came on and went 3-0 on Plouffe before throwing a strike. Plouffe, who leads the team in average and is tied for second in RBIs, then skied a pop fly to shortstop Hanley Ramirez to end the inning.

“We were excited about that situation. He’s a great fastball hitter,” Twins manager Ron Gardenhire said. “That’s his situation, that’s what he needs to do for us. I’m glad that he was willing to take that rip.”

Plouffe atoned for the popup by doubling home two runs with two outs in the ninth, but Kenley Jansen got Chris Colabello to ground out to earn his 10th save in 12 chances.

Doubleheader scheduled today: Mike Pelfrey (0-2, 7.32) will start the first game of Thursday’s doubleheader for Minnesota, and Kris Johnson will make his debut in the nightcap.