Doctors: Various factors figure into Carter cancer treatment

Published 10:06 am Thursday, August 13, 2015

ATLANTA — Determining what treatment to pursue for former President Jimmy Carter’s cancer will depend on its type, its origin and factors such as age and health, doctors said.

Carter, 90, announced Wednesday that recent liver surgery found cancer that has spread to other parts of his body.

“I will be rearranging my schedule as necessary so I can undergo treatment by physicians at Emory Healthcare,”Carter said in the statement released by the Carter Center in Atlanta.

Jimmy Carter

Jimmy Carter

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The statement indicates that the 39th president’s cancer is widespread but not where it originated, or even whether that is known at this point. The liver is often a place where cancer spreads and less commonly is the primary source of it.

Dr. Len Lichtenfeld, deputy chief medical officer of the American Cancer Society, said “there’s a lot we don’t know,” but the first task likely will be determining where the cancer originated, which can help determine what treatmentCarter may be eligible for. Sometimes the primary site can’t be determined, so genetic analysis of the tumor might be done to see what mutations are driving it and what drugs might target those mutations.

“Given the president’s age, any treatments, their potential and their impacts, will undoubtedly be discussed carefully with him and his family,” Lichtenfeld said.

Age by itself does not preclude successful cancer treatment, said Dr. Lodovico Balducci, a specialist on treating cancer in the elderly at the Moffitt Cancer Center in Tampa. Much depends on the patient’s “biological” age versus his actual years, he said.

“A man 90 years old normally would have a life expectancy of two or three years, but Jimmy Carter is probably much younger than that” in terms of his function, Balducci said. “If he tolerated liver surgery, I imagine he has a relatively good tolerance” to other treatments that might be tried. For example, Moffitt has developed a scoring system to estimate how well an older person would tolerate chemotherapy and the risk of serious side effects.

The first task is to determine whether the cancer is curable, “which is unlikely with metastatic cancer,” or if it is possible to meaningfully prolong the life through surgery or other treatments, Balducci said. “Cancer in a 90-year-old is a serious problem, but that does not mean a 90-year-old cannot benefit from treatment.”

Carter’s statement said further information will be provided when more facts are known, “possibly next week.”

Despite remaining active through the years, Carter’s health has recently become the subject of speculation. In May, he was forced to cut short an election observation visit to Guyana when he developed a bad cold.