SAN JOSE, Calif.  — Rising floodwaters sent at least 14,000 residents fleeing inundated homes in San Jose, California, and forced the shutdown of a major freeway Wednesday.

U.S. 101 was closed in both directions south of San Francisco because of water across lanes and officials said there was no estimate when the key commuter artery into Silicon Valley would reopen.

Authorities went door-to-door overnight ordering thousands to seek higher ground as creeks and reservoirs overtopped their banks and sent chest-deep water into neighborhoods.

The region got a brief break from persistent downpours, but flood warnings were in place through Saturday because waterways were overtaxed.

At least 225 residents were taken to dry land Tuesday and rinsed with soap and water to prevent them from being sickened by floodwaters that had traveled through engine fuel, garbage, debris and over sewer lines, said Fire Captain Mitch Matlow. No major injuries were reported.

“The water started to seep in the driveway, and then it started to creep up into the front door. It kept getting worse and worse,” said Alex Hilario, who walked in knee-high water to get to his car and leave.

Meanwhile several other communities downstream from a Northern California reservoir gushing water for the first time in 20 years braced for flash floods and evacuations. The surge released from Don Pedro Dam into the Tuolumne River in the foothills east of Modesto was expected to reach overtopped levees later in the day.

Katie Whitley, who manages the Driftwood Mobile Home Park in Modesto, said residents nearest the river have been moving their trailers out since the start of the weekend.

“We’re just holding our own,” Whitley told the Los Angeles Times. “That’s what we have to do. You just have to hope for the best. But you can expect it when you live on the river.”

The water released from Don Pedro is expected to reach its peak along a stretch near Vernalis that’s already at danger stage, said Tim Daly, a spokesman for the San Joaquin County Office of Emergency Services. The water isn’t expected to spill over the levees but rather increase pressure on them, causing possible breaks in any weak places.

The Anderson Dam in Santa Clara County reached capacity over the weekend, and after heavy rain, it began overflowing into the Coyote Creek.