MOCOA, Colombia — Jose Albeiro Vargas last saw his grandson the night a fierce rain unleashed havoc on this small city surrounded by rivers and mountains in southern Colombia.

From what Vargas has been able to gather, the torrents of mud, water and debris unleashed on the city of Mocoa by the rain-swollen river swept away his 18-month-old grandson, Jadir Estiven. On Sunday, Vargas was searching for the boy and the infant’s young mother, his daughter. The baby’s father survived.

“They were hit by the strongest avalanche,” said Vargas, a clothing store owner who was so tired from the search effort that he could barely open his eyes.

He is far from the only person in Mocoa searching desperately for young loved ones. At least 43 children were among the confirmed dead from the devastating flood, according to President Juan Manuel Santos. Santos later wrote on his Twitter account that he had been informed the overall death toll had increased to 254.

The young may have been particularly vulnerable in this disaster because nearly all were in bed when the floods surged through the city of 40,000 Friday night and early Saturday.

Maria Cordoba, 52, said two of her nephews, ages 6 and 11, were killed when their house was destroyed. “The mother as well was totally beaten up” but managed to save her 18-month-old baby, she said while at the river trying to clean items she salvaged from her home.

The death toll from the flood, one of the worst natural disasters to strike the country in years, was expected to rise as many people were injured or remained unaccounted for, and bodies were still being pulled from the thick mud, tree limbs and debris that covered much of the city. The deluge smashed houses, tore trees out by the roots and washed cars and trucks away.

Search-and-rescue teams combed through the debris and helped people who had been clawing at huge mounds of mud by hand.

“People went to their houses and found nothing but the floor,” said Gilma Diaz, a 42-year-old from another town who came to search for a cousin.

Dozens stood in the door of a hospital, hoping for news of family members who were not on the list of those confirmed dead or injured. Others frantically knocked on relatives’ doors, hoping to find someone with information about their loved ones.

A rescue worker in an orange jumpsuit emerged from one search area with the body of an infant wrapped in a towel. Not far away, Abelardo Solarte, a 48-year-old resident of Mocoa, held a child’s shoe as he helped clear debris.