MINNEAPOLIS — Miguel Sano hit two of the Twins’ season high-tying six home runs, including an inside-the-park dash by Byron Buxton, and Minnesota powered past the Arizona Diamondbacks 10-3 Friday night.

Eduardo Escobar, Max Kepler and Brian Dozier also went deep for Minnesota. Buxton finished a single shy of the cycle.

David Peralta had three hits for Arizona, including a home run.

Leading 4-3 in the seventh, Sano hit the first pitch from reliever David Hernandez 452 feet into the second deck in left-center for two runs. Escobar added a two-run shot two batters later for an 8-3 lead.

Sano hit one even further, 474 feet into the third deck, in the eighth for his first multi-homer game this season and third of his career.

Minnesota also hit six home runs May 2 against Oakland.

Down 3-2 in the fourth, Buxton hit a ball high off the wall in right-center that rolled toward center field. As A.J. Pollock gave chase, Buxton circled the bases in 13.85 seconds, the fastest ever tracked by MLB Statcast, narrowly beating the throw by sliding headfirst across home plate.

Buxton scored after doubling in the sixth, the first of 25 inherited runners to score this year against Diamondbacks reliever Jorge De La Rosa.

Seeking to become the first Twin since Michael Cuddyer on May 22, 2009, to accomplish the cycle, Buxton, who tripled in the second, lined out to Daniel Descalso in the seventh.

Arizona starter Zack Godley (5-6) tied a career high by striking out 10, but allowed four earned runs in 5 1-3 innings.

Twins starter Ervin Santana (13-7) allowed three earned runs and seven hits in six innings.