What’s the best ATS bet to make, considering each of the 14 matchups on the NFL’s Week 5 slate? Our favorite choice against the spread is Patriots -1, but we have plenty more tips for you, which could lead to parlay opportunities, below.

NFL Picks Against the Spread – Week 5

Jump to Matchup:

Pick: Patriots -1 vs. Dolphins

• Matchup: Miami Dolphins at New England Patriots
• Projected Winner & Margin: Patriots by 4.0 points (Bet on this game at BetMGM)
• Spread: Patriots -1
• Time: 1:00 p.m. ET
• Date: Oct. 6
• TV Channel: FOX
• Live Stream: Watch this game on Fubo (Regional restrictions may apply)

Pick: Texans +1 vs. Bills

• Matchup: Buffalo Bills at Houston Texans
• Projected Winner & Margin: Texans by 2.1 points (Bet on this game at BetMGM)
• Spread: Bills -1
• Time: 1:00 p.m. ET
• Date: Oct. 6
• TV Channel: CBS
• Live Stream: Paramount+ | Fubo (Regional restrictions may apply)

Pick: Buccaneers +1.5 vs. Falcons

• Matchup: Tampa Bay Buccaneers at Atlanta Falcons
• Projected Winner & Margin: Falcons by 0.7 points (Bet on this game at BetMGM)
• Spread: Falcons -1.5
• Time: 8:15 p.m. ET
• Date: Oct. 3
• TV Channel: Amazon Prime Video
• Live Stream: Watch this game on Prime Video (Regional restrictions may apply)

Pick: Vikings -2.5 vs. Jets

• Matchup: New York Jets vs. Minnesota Vikings
• Projected Winner & Margin: Vikings by 5.2 points (Bet on this game at BetMGM)
• Spread: Vikings -2.5
• Time: 9:30 a.m. ET
• Date: Oct. 6
• TV Channel: NFL Network
• Live Stream: Watch this game on Fubo (Regional restrictions may apply)

Pick: Bengals +2.5 vs. Ravens

• Matchup: Baltimore Ravens at Cincinnati Bengals
• Projected Winner & Margin: Ravens by 1.2 points (Bet on this game at BetMGM)
• Spread: Ravens -2.5
• Time: 1:00 p.m. ET
• Date: Oct. 6
• TV Channel: CBS
• Live Stream: Paramount+ | Fubo (Regional restrictions may apply)

Pick: Steelers -2.5 vs. Cowboys

• Matchup: Dallas Cowboys at Pittsburgh Steelers
• Projected Winner & Margin: Steelers by 6.0 points (Bet on this game at BetMGM)
• Spread: Steelers -2.5
• Time: 8:20 p.m. ET
• Date: Oct. 6
• TV Channel: NBC
• Live Stream: Watch this game on Fubo (Regional restrictions may apply)

Pick: Colts +3 vs. Jaguars

• Matchup: Indianapolis Colts at Jacksonville Jaguars
• Projected Winner & Margin: Colts by 3.2 points (Bet on this game at BetMGM)
• Spread: Jaguars -3
• Time: 1:00 p.m. ET
• Date: Oct. 6
• TV Channel: CBS
• Live Stream: Paramount+ | Fubo (Regional restrictions may apply)

Pick: Broncos -3 vs. Raiders

• Matchup: Las Vegas Raiders at Denver Broncos
• Projected Winner & Margin: Broncos by 6.8 points (Bet on this game at BetMGM)
• Spread: Broncos -3
• Time: 4:05 p.m. ET
• Date: Oct. 6
• TV Channel: FOX
• Live Stream: Watch this game on Fubo (Regional restrictions may apply)

Pick: Commanders -3.5 vs. Browns

• Matchup: Cleveland Browns at Washington Commanders
• Projected Winner & Margin: Commanders by 4.4 points (Bet on this game at BetMGM)
• Spread: Commanders -3.5
• Time: 1:00 p.m. ET
• Date: Oct. 6
• TV Channel: FOX
• Live Stream: Watch this game on Fubo (Regional restrictions may apply)

Pick: Rams +3.5 vs. Packers

• Matchup: Green Bay Packers at Los Angeles Rams
• Projected Winner & Margin: Rams by 0.5 points (Bet on this game at BetMGM)
• Spread: Packers -3.5
• Time: 4:25 p.m. ET
• Date: Oct. 6
• TV Channel: CBS
• Live Stream: Paramount+ | Fubo (Regional restrictions may apply)

Pick: Bears -4 vs. Panthers

• Matchup: Carolina Panthers at Chicago Bears
• Projected Winner & Margin: Bears by 7.9 points (Bet on this game at BetMGM)
• Spread: Bears -4
• Time: 1:00 p.m. ET
• Date: Oct. 6
• TV Channel: FOX
• Live Stream: Watch this game on Fubo (Regional restrictions may apply)

Pick: Saints +5 vs. Chiefs

• Matchup: New Orleans Saints at Kansas City Chiefs
• Projected Winner & Margin: Chiefs by 4.6 points (Bet on this game at BetMGM)
• Spread: Chiefs -5
• Time: 8:15 p.m. ET
• Date: Oct. 7
• TV Channel: ESPN
• Live Stream: Watch this game on Fubo (Regional restrictions may apply)

Pick: Seahawks -6 vs. Giants

• Matchup: New York Giants at Seattle Seahawks
• Projected Winner & Margin: Seahawks by 7.0 points (Bet on this game at BetMGM)
• Spread: Seahawks -6
• Time: 4:25 p.m. ET
• Date: Oct. 6
• TV Channel: CBS
• Live Stream: Paramount+ | Fubo (Regional restrictions may apply)

Pick: 49ers -7.5 vs. Cardinals

• Matchup: Arizona Cardinals at San Francisco 49ers
• Projected Winner & Margin: 49ers by 10.3 points (Bet on this game at BetMGM)
• Spread: 49ers -7.5
• Time: 4:05 p.m. ET
• Date: Oct. 6
• TV Channel: FOX
• Live Stream: Watch this game on Fubo (Regional restrictions may apply)

Catch every NFL touchdown with NFL RedZone on Fubo.

Not all offers available in all states, please visit BetMGM for the latest promotions for your area. Must be 21+ to gamble, please wager responsibly. If you or someone you know has a gambling problem, contact 1-800-GAMBLER.